effect Noun
How does Alimta work ?
The active substance in Alimta , pemetrexed , is a cytotoxic medicine ( a medicine that kills cells that are dividing , such as cancer cells ) , which belongs to the group antimetabolites .
In the body , pemetrexed is converted into an active form that blocks the activity of the enzymes that are involved in producing nucleotides ( the building blocks of DNA and RNA , the genetic material of cells ) .
How has Alimta been studied ?
For the treatment of malignant pleural mesothelioma , Alimta has been studied in one main study in 456 patients who had not received chemotherapy for their disease before .
The effects of Alimta in combination with cisplatin were compared with those of cisplatin alone .
For the treatment of non-small cell lung cancer , the effects of Alimta were compared with those of docetaxel ( another anticancer medicine ) in one study involving 571 patients with locally advanced or metastatic disease who had received chemotherapy in the past .
Alimta was also compared with gemcitabine ( another anticancer medicine ) , both in combination with cisplatin , in a study involving 1,725 patients who had not received chemotherapy for lung cancer in the past .